Sandrena Gel (Estradiol Gel Sachets)
Where and how to apply your Sandrena Gel for effective oestrogen absorption
What is Sandrena Gel?
Sandrena is a topical estradiol gel that comes in individual unit-dose sachets. Like Estrogel, it delivers oestrogen through the skin as part of menopausal hormone therapy (MHT). Each sachet contains a fixed dose of estradiol — your doctor will specify the strength and how many sachets to use each day.
🌿 Important reminder
If you still have a uterus, you will usually also need a progesterone (such as Prometrium) alongside Sandrena Gel. Please confirm this with your doctor.
Where to Apply
Sandrena is applied to the outer thigh or lower body. It should not be applied to the arms or upper body.
Rotate daily — apply to the left thigh one day, and the right thigh the next, or as directed by your doctor. This reduces the risk of local skin irritation.
❌ Do not apply to
Face, neck, or scalp
Breasts or chest
Genital or rectal areas
Skin that is broken, irritated, sunburnt, or recently shaved
How to Apply – Step by Step
Check your dose
Use the number of sachets prescribed by your doctor. Do not change the number without checking first.
Clean and dry skin
Apply to clean, dry skin on the outer thigh or lower body area as directed. Wait until skin is completely dry after washing.
Open the sachet
Tear open the sachet and squeeze the entire contents onto the application site (outer thigh or lower body).
Spread the gel
Spread the gel gently over an area roughly the size of two hand-prints. Rub in gently but do not massage vigorously.
Allow to dry
Allow the gel to dry fully for 2–3 minutes before dressing. Do not cover with tight clothing until dry.
Wash hands
Wash your hands thoroughly with soap and water after applying to prevent accidental transfer to others.
When to Apply
Apply once daily, at approximately the same time each day.
Avoid swimming, bathing, or showering for at least 1 hour after application.
If you miss a dose, apply as soon as you remember on the same day. Do not double up the following day.
Reference Graphic
Sandrena Gel application to outer thighs — see panel 2 of the Arami Hormone Therapy Guide
Transfer Precautions
⚠️ Skin-to-skin transfer risk
Oestrogen gel can transfer to others through direct skin contact. Keep the application area covered or avoid close contact for at least 1–2 hours after applying. Be especially careful around young children and male partners.
Storage and Safety
Store sachets at room temperature (below 25°C).
Keep out of reach of children and pets.
The gel contains alcohol — do not use near open flames until dry.
Dispose of used sachets safely, out of reach of children.
Questions about Sandrena Gel or your hormone therapy?
Book a review appointment to ensure your MHT is working effectively and is right for you.
Medical Disclaimer
This information is general in nature and does not replace professional medical advice. Always follow the specific instructions provided by your doctor or pharmacist, and refer to the Consumer Medicines Information (CMI) leaflet supplied with your medication. If you experience unexpected side effects or have concerns about your treatment, contact your healthcare provider promptly.